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Ketone bodies provide energy for
body's needs when there is a total food restriction, carbohydrate restriction, and/or long enough physical effort.
In
beginning of ketosis, ketones provide up to 75% of total energy requirement, including energy required by
brain. Most dieticians say that carbohydrate is
only fuel for
nerve cells but it is not true. It's a preferred fuel, yes, but not
only one. If there are little or no carbohydrates, all tissues of
body including brain tissue can adapt to using alternative fuel.
As
body undergoes
process of adaptation to ketosis,
amount of carbohydrates required reduces. This explains why brain fog and muscle weakness can occur in
beginning of ketosis but becomes very rare after a week or two. In fact, it's true that a diet is considered low carb if it contains less than 100 carb grams a day, but it's only true until
adaptation to ketosis develops. After it is completed,
carb requirement is around 40 grams. None of non-clinical low carb diets takes this fact into account.
After 1-2 weeks, as
process of adaptation to ketosis develops and
tissues no longer rely on carbohydrates for fuel, they send less signals requesting
beta-cells in
pancreas to release insulin -- resulting in decrease of insulin concentration in
blood.
Low insulin level frees its antagonistic fat burning hormones from suppression resulting in increased levels of glucagon, growth hormone, catecholamines, and glucocorticoid.
Glucagon is
most important insulin antagonist; it's up to glucagon to control fatty acids' release from fat stores to be burnt for fuel. So, as glucagon release increases, insulin goes down. It is thought that to initiate ketosis, carbohydrate intake should be reduced to less than 30g/day.
However, there's a most important condition grossly overlooked by
authors of low carb diets. Any food is either ketogenic or glucogenic depending on it influence on
competition between glucagon and insulin. To make ketosis possible, a meal should contain at least 1.5 g of fat per every 1 g of protein plus carbohydrate combined.
Only that or higher of a ratio makes food ketogenic enough to allow eating without portion and calorie control. Foods with ketogenic indexes below 1 promote insulin release and are essentially anti-ketogenic. Foods with indexes between 1 and 1.5, though not anti-ketogenic, require calorie control since their ketogenic properties are not strong enough to significantly suppress
carbohydrate metabolic pathway and mobilize body fat for fuel thus causing healthy hunger decrease.

Dr. Tanya Zilberter is a researcher, health educator, exercise physiologist, and scientific journalist. In health sciences since 1972, Dr. Zilberter authored several hundred scientific and popular publications, including four print books and more than a dozen of eBooks. She writes for bantadiet.com and dietandbody.com